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Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

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Published in 2017 at "Frontiers in Psychiatry"

DOI: 10.3389/fpsyt.2017.00083

Abstract: Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neurovascular… read more here.

Keywords: schizophrenia; hyperpermeability; brain; dysfunction blood ... See more keywords