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Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart

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0 Published in 2017 at "Heart Failure Reviews"

DOI: 10.1007/s10741-017-9663-y

Abstract: The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart… read more here.

Keywords: heart; dysfunction diabetic; diabetic heart; contractile dysfunction ... See more keywords

Mitochondrial dysfunction and diabetic retinopathy.

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0 Published in 2017 at "Mitochondrion"

DOI: 10.1016/j.mito.2016.07.011

Abstract: Mitochondrial dysfunction may predispose to the development of diabetes mellitus with the accompanying risk for developing diabetic retinopathy or may contribute directly to the diabetic metabolic dysregulation and thereby increase the risk of diabetic late… read more here.

Keywords: dysfunction diabetic; diabetic retinopathy; mitochondrial dysfunction;

Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation

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0 Published in 2019 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2019.08.003

Abstract: Objective The impact of diabetes mellitus on the central nervous system is less widely studied than in the peripheral nervous system, but there is increasing evidence that it elevates the risk of developing cognitive deficits.… read more here.

Keywords: dysfunction diabetic; cognitive dysfunction; pyridoxamine treatment;

A3 adenosine receptor allosteric modulator CF602 reverses erectile dysfunction in a diabetic rat model

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0 Published in 2022 at "Andrologia"

DOI: 10.1111/and.14498

Abstract: Adenosine plays a major role in erection by binding to its receptors and activating pathways resulting in increased arterial blood flow and intracavernosal pressure (ICP). CF602, an allosteric modulator of the A3 adenosine receptor (A3AR),… read more here.

Keywords: cf602; allosteric modulator; dysfunction diabetic; erectile dysfunction ... See more keywords

Endothelial Dysfunction in Diabetic Retinopathy

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0 Published in 2020 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2020.00591

Abstract: Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and… read more here.

Keywords: dysfunction diabetic; diabetic retinopathy; dysfunction; endothelial dysfunction ... See more keywords