Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abe7548
Abstract: IFN-I–NRF2 signaling imbalances drive immunometabolic dysfunction, inflammation, and premature aging in POLG mutator mice. Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune… read more here.
Keywords: type interferon; mutator; dysfunction; dysfunction inflammation ... See more keywords
OP0006 IMPROVEMENT OF ENDOTHELIAL DYSFUNCTION AND INFLAMMATION IN PSORIATIC ARTHRITIS: IMPROVE – PSA STUDY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5880
Abstract: Background Cardiovascular (CV) disease is leading cause of death in Psoriatic Arthritis (PsA)1. Chronic inflammation in PsA is associated with vascular endothelial dysfunction and enhanced CV risk. However, the therapeutic options to treat this enhanced… read more here.
Keywords: rosuvastatin olmesartan; psa; endothelial dysfunction; dysfunction inflammation ... See more keywords
Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19312
Abstract: Background: Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on biomarkers of endothelial dysfunction and inflammation in hypertensive children… read more here.
Keywords: placebo; dysfunction; endothelial dysfunction; biomarkers endothelial ... See more keywords