The Treatment of Sleep Dysfunction in Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00959-7
Abstract: Sleep dysfunction is highly prevalent across the spectrum of neurodegenerative conditions and is a key determinant of quality of life for both patients and their families. Mounting recent evidence also suggests that such dysfunction exacerbates… read more here.
Keywords: dysfunction; sleep dysfunction; neurodegenerative disorders; treatment sleep ... See more keywords
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Brain"
DOI: 10.1186/s13041-019-0504-x
Abstract: Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes… read more here.
Keywords: autophagic endo; disease; lysosomal dysfunction; clearance ... See more keywords
P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?
Sign Up to like & getrecommendations! Published in 2017 at "Aging and Disease"
DOI: 10.14336/ad.2016.1120
Abstract: Neurodegenerative diseases are a heterogeneous, mostly age-associated group of disorders characterized by progressive neuronal loss, the most prevalent being Alzheimer disease. It is anticipated that, with continuously increasing life expectancy, these diseases will pose a… read more here.
Keywords: changes p53; p53 dysfunction; neurodegenerative diseases; diseases cause ... See more keywords
Neurovascular Unit Dysfunction and Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00334
Abstract: The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral… read more here.
Keywords: unit; dysfunction; neurodegenerative disorders; neurovascular unit ... See more keywords
Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012603
Abstract: Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders, including Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, multisystem atrophy, and progressive supranuclear palsy. This article is concerned specifically with mitochondrial… read more here.
Keywords: supplementation; role; dysfunction neurodegenerative; mitochondrial dysfunction ... See more keywords
Endothelial Dysfunction in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032909
Abstract: The cerebral vascular system stringently regulates cerebral blood flow (CBF). The components of the blood–brain barrier (BBB) protect the brain from pathogenic infections and harmful substances, efflux waste, and exchange substances; however, diseases develop in… read more here.
Keywords: blood vessel; vascular dysfunction; dysfunction neurodegenerative; dysfunction ... See more keywords
Overcoming mitochondrial dysfunction in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.360279
Abstract: Due to their intense electrical activity, neurons have high energy demands. This requirement makes them particularly sensitive to mitochondrial dysfunction. Like all eukaryotic cells, neurons have intrinsic mechanisms to mitigate the impact of mitochondrial dysfunction… read more here.
Keywords: dysfunction neurodegenerative; overcoming mitochondrial; mitochondrial dysfunction; dysfunction ... See more keywords