Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity.
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DOI: 10.1016/j.ceca.2018.06.003
Abstract: A novel pathway of methylglyoxal (MGX)-induced apoptosis via sarcoplasmic reticulum Ca2+-ATPase (SERCA) is presented. Interaction of SERCA1 with MGX was investigated by molecular docking and experimentally in a cell-free system. MGX concentration- and time-dependently decreased… read more here.
Keywords: mgx; methylglyoxal; decrease; dysfunction serca ... See more keywords