Nano-based rescue of dysfunctional autophagy in chronic obstructive lung diseases
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2016.1223040
Abstract: ABSTRACT Introduction: ΔF508-CFTR (cystic fibrosis transmembrane conductance regulator) is a common CF-mutation that is known to induce oxidative-inflammatory stress through activation of reactive oxygen species (ROS), which induces autophagy-impairment resulting in accumulation of CFTR in… read more here.
Keywords: rescue dysfunctional; dysfunctional autophagy; delivery; drug ... See more keywords
Dysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.602116
Abstract: Autophagy and endolysosomal trafficking are crucial in neuronal development, function and survival. These processes ensure efficient removal of misfolded aggregation-prone proteins and damaged organelles, such as dysfunctional mitochondria, thus allowing the maintenance of proper cellular… read more here.
Keywords: endolysosomal system; dysfunctional autophagy; system neurodegenerative; neurodegenerative diseases ... See more keywords