Analgesic effects of ASP3662, a novel 11β‐hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14448
Abstract: Glucocorticoids are a major class of stress hormones known to participate in stress‐induced hyperalgesia. Although 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1) is a key enzyme in the intracellular regeneration of glucocorticoids in the CNS, its role in… read more here.
Keywords: effects asp3662; dysfunctional pain; neuropathic dysfunctional; asp3662 novel ... See more keywords
MicroRNAs in functional and dysfunctional pain.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.356.6343.1134-r
Abstract: Pain Regulation Pain serves the useful purpose of alerting us to danger. Chronic pain, however, can arise from dysfunctional responses. Peng et al. found that a cluster of microRNAs regulates the gene networks behind both… read more here.
Keywords: dysfunctional pain; micrornas functional; pain; functional dysfunctional ... See more keywords