Dysfunctional γ-Secretase in Familial Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2511-1
Abstract: Genetics strongly implicate the amyloid β-peptide (Aβ) in the pathogenesis of Alzheimer’s disease. Dominant missense mutation in the presenilins and the amyloid precursor protein (APP) cause early-onset familial Alzheimer’s disease (FAD). As presenilin is the… read more here.
Keywords: alzheimer disease; familial alzheimer; secretase; dysfunctional secretase ... See more keywords