Two Cases of TMEM151A ‐Associated Paroxysmal Dyskinesia in a Single‐Center Series of PRRT2‐Negative Patients
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13705
Abstract: Paroxysmal dyskinesia (PD) refers to a group of heterogeneous syndromes characterized by recurrent attacks of dystonia and/or chorea, without loss of consciousness. 1 PD are classi fi ed by trig-gers as paroxysmal kinesigenic dyskinesia (PKD),… read more here.
Keywords: tmem151a associated; dyskinesia; cases tmem151a; prrt2 negative ... See more keywords
Levodopa-induced dyskinesia: clinical features, incidence, and risk factors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1900-6
Abstract: Symptoms of Parkinson’s disease have been controlled with levodopa for many years; however, motor complications consisting of wearing off of medication effect and dyskinesias tend to occur within a few years of starting levodopa. Motor… read more here.
Keywords: disease; risk factors; levodopa induced; dyskinesia ... See more keywords
Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00333-1
Abstract: Animal models of haloperidol (HAL)-induced neurotoxicity and orofacial dyskinesia (OD) have long been used to study human tardive dyskinesia (TD). Similar to patients with TD, these models show strong pathophysiological characteristics such as striatal oxidative… read more here.
Keywords: neurotoxicity orofacial; orofacial dyskinesia; induced neurotoxicity; hal induced ... See more keywords
Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.03.002
Abstract: HighlightsSelegiline extends l‐Dopa‐induced shortened on time in hemi‐parkinsonian rats.Selegiline does not exacerbate l‐Dopa‐induced dyskinesia in hemi‐parkinsonian rats.Selegiline does not alter PDy and Arc mRNA expression in the lesioned striatum. ABSTRACT 3,4‐Dihydroxy‐l‐phenylalanine (l‐Dopa) remains the most… read more here.
Keywords: time without; time; dopa induced; lesioned rats ... See more keywords
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113327
Abstract: Numerous genes, and alterations in their expression, have been identified as risk factors for developing levodopa-induced dyskinesia (LID). However, our understanding of the complexities of molecular changes remains insufficient for development of clinical treatment. In… read more here.
Keywords: levodopa induced; fosb; expression; dyskinesia ... See more keywords
Anti-dyskinetic efficacy of 5-HT3 receptor antagonist in the hemi-parkinsonian rat model
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2018.12.001
Abstract: Parkinson's disease is a progressive debilitative neurodegenerative disease characterised mostly with bradykinesia, tremor, catatonia, drooping posture, unsteady gate and unstable steps. Levodopa has been proven to be among the most effective and acceptable treatment that… read more here.
Keywords: ondansetron; disease; anti dyskinetic; test ... See more keywords
Lithium monotherapy-induced tardive dyskinesia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.10.094
Abstract: Tardive dyskinesia is a movement disorder that develops during the course of long-term treatment with neuroleptic agents and is characterized primarily by choreiform and athetotic movements. We report the case of a 68-year old female… read more here.
Keywords: lithium monotherapy; monotherapy induced; dyskinesia; tardive dyskinesia ... See more keywords
Reprint of: Clinical management of tardive dyskinesia: Five steps to success
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2018.02.037
Abstract: Tardive dyskinesia (TD) has long been thought to be a generally irreversible consequence of the use of dopamine receptor blocking agents. There is now an opportunity to successfully manage this condition with agents approved by… read more here.
Keywords: management tardive; clinical management; reprint clinical; dyskinesia five ... See more keywords
Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.03.006
Abstract: Catechol-O-methyltransferase (COMT) degrades dopamine and its precursor l-DOPA and plays a critical role in regulating synaptic dopamine actions. We investigated the effects of heightened levels of COMT on dopamine-regulated motor behaviors and molecular alterations in… read more here.
Keywords: human comt; confers heightened; comt; mice ... See more keywords
Zonisamide Therapy for Patients With Paroxysmal Kinesigenic Dyskinesia.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2020.06.017
Abstract: BACKGROUND We evaluated zonisamide therapy in patients with paroxysmal kinesigenic dyskinesia (PKD). METHODS We analyzed zonisamide therapy in 17 patients with PKD at Saitama Children's Medical Center between November 1994 and April 2020. We collected… read more here.
Keywords: commencement; zonisamide therapy; zonisamide; therapy patients ... See more keywords
Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-020-0641-9
Abstract: Cause of complex dyskinesia remains elusive in some patients. A homozygous missense variant leading to drastic decrease of PDE2A enzymatic activity was reported in one patient with childhood-onset choreodystonia preceded by paroxysmal dyskinesia and associated… read more here.
Keywords: biallelic pde2a; cause; pde2a variants; paroxysmal dyskinesia ... See more keywords