Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02162-7
Abstract: PURPOSE Antagonising serotonin (5-HT) type 2A receptors (5-HT2AR) is an effective strategy to alleviate both dyskinesia and psychosis in Parkinson's disease (PD). We have recently shown that activation of metabotropic glutamate 2 receptors (mGluR2), via… read more here.
Keywords: ht2ar antagonism; emd 281; mglur2; dyskinesia psychosis ... See more keywords
Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism
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DOI: 10.1016/j.neuropharm.2019.107725
Abstract: Selective blockade of serotonin 2A (5-HT2A) receptors is a promising strategy to reduce L-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia and has shown efficacy in a Phase III clinical trial for dopaminergic psychosis in Parkinson's disease (PD). However, pre-clinical… read more here.
Keywords: mglu2 receptors; activation mglu2; dyskinesia psychosis; mglu2 ... See more keywords
Combined 5-HT2A and mGlu2 modulation for the treatment of dyskinesia and psychosis in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108465
Abstract: Antagonising the serotonin 2A (5-HT2A) receptor is an efficacious way to alleviate dyskinesia and psychosis in Parkinson's disease (PD). However, previous research indicates that there might be a limit to the effects conferred by this… read more here.
Keywords: 281 014; emd 281; dyskinesia psychosis;