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Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

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0 Published in 2017 at "Neurology"

DOI: 10.1212/wnl.0000000000003491

Abstract: Objective: To investigate mitophagy in 5 patients with severe dominantly inherited optic atrophy (DOA), caused by depletion of OPA1 (a protein that is essential for mitochondrial fusion), compared with healthy controls. Methods: Patients with severe… read more here.

Keywords: opa1 mutations; mitophagy mitochondrial; optic atrophy; dysregulated mitophagy ... See more keywords