Addressing Transcriptional Dysregulation in Cancer through CDK9 Inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00609
Abstract: Undermining transcriptional addiction, the dependence of cancers on selected transcriptional programs, is critically important for addressing cancers with high unmet clinical need. Cyclin-dependent kinase 9 (CDK9) has long been considered an actionable therapeutic target for… read more here.
Keywords: cdk9; transcriptional dysregulation; addressing transcriptional; dysregulation cancer ... See more keywords
Metabolic dysregulation and cancer mortality in a national cohort of blacks and whites
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3807-2
Abstract: BackgroundWe examined the association between metabolic dysregulation and cancer mortality in a prospective cohort of Black and White adults.MethodsA total of 25,038 Black and White adults were included in the analysis. Metabolic dysregulation was defined in… read more here.
Keywords: cancer; metabolic dysregulation; dysregulation cancer; cancer mortality ... See more keywords
Exercise—A Panacea of Metabolic Dysregulation in Cancer: Physiological and Molecular Insights
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DOI: 10.3390/ijms22073469
Abstract: Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits… read more here.
Keywords: panacea metabolic; metabolic dysregulation; exercise panacea; dysregulation cancer ... See more keywords