Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells
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DOI: 10.1016/j.isci.2020.101551
Abstract: Summary Impairment of circadian rhythms impacts carcinogenesis. SMAD4, a clock-controlled gene and central component of the TGFβ canonical pathway, is frequently mutated in pancreatic ductal adenocarcinoma (PDA), leading to decreased survival. Here, we used an… read more here.
Keywords: smad4; dysregulation tgf; tgf; tgf smad4 ... See more keywords