Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin‐deficient mice and Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13099
Abstract: Duchenne muscular dystrophy (DMD) is a fatal disorder caused by absence of functional dystrophin protein. Compensation in dystrophin‐deficient (mdx) mice may be achieved by overexpression of its fetal paralogue, utrophin. Strategies to increase utrophin levels… read more here.
Keywords: mice; muscular dystrophy; dystrophin deficient; duchenne muscular ... See more keywords
Isometric resistance training increases strength and alters histopathology of dystrophin-deficient mouse skeletal muscle.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00948.2018
Abstract: Mutation to the dystrophin gene causes skeletal muscle weakness in patients with Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD). Deliberation continues regarding implications of prescribing exercise for these patients. The purpose of this… read more here.
Keywords: skeletal muscle; strength; muscle; histopathology ... See more keywords
Calcium current properties in dystrophin‐deficient ventricular cardiomyocytes from aged mdx mice
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DOI: 10.14814/phy2.13567
Abstract: Duchenne muscular dystrophy (DMD), caused by mutations in the gene encoding for the cytoskeletal protein dystrophin, is linked with severe cardiac complications including cardiomyopathy development and cardiac arrhythmias. We and others recently reported that currents… read more here.
Keywords: mdx mice; ventricular cardiomyocytes; deficient ventricular; aged mdx ... See more keywords
Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy
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DOI: 10.3390/ijms22010356
Abstract: Dystrophin-deficient cardiomyopathy (DDC) is currently the leading cause of death in patients with dystrophinopathies. Targeting myocardial fibrosis (MF) has become a major therapeutic goal in order to prevent the occurrence of DDC. We aimed to… read more here.
Keywords: raas; deficient cardiomyopathy; role renin; renin angiotensin ... See more keywords
Dystrophin-Deficient Muscular Dystrophy in Two Male Juvenile Brittanys.
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DOI: 10.5326/jaaha-ms-7255
Abstract: A 6 mo old and a 7 mo old male intact Brittany were presented for progressive exercise intolerance, failure to grow, and dysphagia. Creatine kinase activity was markedly and persistently elevated in both dogs. Based… read more here.
Keywords: dystrophy; male; deficient muscular; dystrophin deficient ... See more keywords