The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins
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DOI: 10.1038/cdd.2017.88
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons (MNs) and their target muscles. Misfolded proteins which often form intracellular aggregates are a pathological hallmark of ALS. Disruption of the functional… read more here.
Keywords: homeostasis; e102q sigr1; protein homeostasis; rna binding ... See more keywords