Carboxamide-Bearing Panobinostat Analogues Designed To Interact with E103-D104 at the Cavity Opening of Class I HDAC Isoforms.
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DOI: 10.1021/acsmedchemlett.4c00494
Abstract: Panobinostat (1) inhibits Zn(II)-dependent histone deacetylases (HDACs) which are validated cancer targets. Three sets of 1 analogues containing carboxamide groups designed to form hydrogen bonds with acidic residues (E103, D104) in the cavity opening of… read more here.
Keywords: d104 cavity; class; cavity opening; e103 d104 ... See more keywords