Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation
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DOI: 10.1371/journal.pone.0184605
Abstract: E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the cardiac voltage-gated sodium channel NaV1.5. E1784K shifts the midpoint of the channel conductance-voltage relationship to more depolarized membrane potentials and accelerates the… read more here.
Keywords: voltage; conductance voltage; fast inactivation; e1784k ... See more keywords