Unraveling the Origins of Changing Product Specificity Properties of Arginine Methyltransferase PRMT7 by the E181D and E181D/Q329A Mutations through QM/MM MD and Free-Energy Simulations.
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DOI: 10.1021/acs.jctc.1c01219
Abstract: Arginine methylations can regulate important biological processes and affect many cellular activities, and the enzymes that catalyze the methylations are protein arginine methyltransferases (PRMTs). The biological consequences of arginine methylations depend on the methylation states… read more here.
Keywords: e181d e181d; e181d; product specificity; e181d q329a ... See more keywords