PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis
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DOI: 10.1038/s41420-018-0100-3
Abstract: Expression of the adenovirus E1A oncogene sensitizes tumor cells to innate immune rejection by apoptosis induced by macrophage-produced tumor necrosis factor (TNF)-α and nitric oxide (NO). E1A sensitizes cells to TNF-α and NO through two… read more here.
Keywords: caspase; apoptosis; mitochondrial injury; e1a ... See more keywords
Overexpression of Adenoviral E1A Sensitizes E1A+Ras-Transformed Cells to the Action of Histone Deacetylase Inhibitors
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DOI: 10.32607/20758251-2018-10-4-70-78
Abstract: The adenoviral E1A protein induces cell proliferation, transformation, and tumor formation in rodents, on the one hand. On the other hand, E1A expression increases cell sensitivity to a number of cytotoxic agents. Therefore, E1A is… read more here.
Keywords: e1a expression; e1a; hdac inhibitors; adenoviral e1a ... See more keywords
Ras Participates in the Regulation of the Stability of Adenoviral Protein E1A via MAP-kinase ERK
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DOI: 10.32607/actanaturae.11675
Abstract: The E1A adenoviral protein required for the initiation of the viral life cycle is being actively studied as a sensitizing agent in the combination therapy of cancer, and tumors with activated Ras in particular. We… read more here.
Keywords: kinase; regulation; erk; stability ... See more keywords