A novel oncolytic adenovirus targeting Wnt signaling effectively inhibits cancer-stem like cell growth via metastasis, apoptosis and autophagy in HCC models.
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DOI: 10.1016/j.bbrc.2017.07.041
Abstract: Cancer stem cells (CSCs), which are highly differentiated and self-renewing, play an important role in the occurrence, therapeutic resistant and metastasis of hepatacellular carcinoma (HCC). Oncolytic adenoviruses have targeted killing effect on tumor cells, and… read more here.
Keywords: wnt e1a; adenovirus; e1a 24bp; cancer ... See more keywords