Articles with "e2012" as a keyword



Understanding the Modulatory Role of E2012 on the γ-Secretase-Substrate Interaction

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Published in 2024 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.3c01993

Abstract: Allosteric modulation plays a critical role in enzyme functionality and requires a deep understanding of the interactions between the active and allosteric sites. γ-Secretase (GS) is a key therapeutic target in the treatment of Alzheimer's… read more here.

Keywords: e2012; role; understanding modulatory; modulatory role ... See more keywords