The primary cause of muscle disfunction associated with substitutions E240K and R244G in tropomyosin is aberrant behavior of tropomyosin and response of actin and myosin during ATPase cycle.
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DOI: 10.1016/j.abb.2018.03.002
Abstract: Using the polarized photometry technique we have studied the effects of two amino acid replacements, E240K and R244G, in tropomyosin (Tpm1.1) on the position of Tpm1.1 on troponin-free actin filaments and the spatial arrangement of… read more here.
Keywords: e240k r244g; actin; muscle; tropomyosin ... See more keywords