SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.124
Abstract: SUMMARY Acute lymphoblastic leukemia (ALL) is associated with significant morbidity and mortality, necessitating further improvements in diagnosis and therapy. Targeted therapies directed against chromatin regulators are emerging as promising approaches in preclinical studies and early… read more here.
Keywords: leukemia; acute; cell cycle; e2a pbx1 ... See more keywords
Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842
Sign Up to like & getrecommendations! Published in 2024 at "Haematologica"
DOI: 10.3324/haematol.2023.283647
Abstract: t(1;19)(q23;p13) is one of the most common translocation genes in childhood acute lymphoblastic leukemia (ALL) and is also present in acute myeloid leukemia (AML) and mixed-phenotype acute leukemia (MPAL). This translocation results in the formation… read more here.
Keywords: pbx1; leukemia; e2a pbx1; he2a pbx1 ... See more keywords