O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61022-7
Abstract: The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated expression of the transcription factor… read more here.
Keywords: e2f pathway; foxk1; glcnacylation; e2f target ... See more keywords
The Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.655630
Abstract: Gastric cancer is the most common malignant tumor in the digestive tract, with very high morbidity and mortality in developing countries. The pathogenesis of gastric cancer is a complex biological process mediated by abnormal regulation… read more here.
Keywords: gastric cancer; e2f pathway; clinical implications; cancer ... See more keywords
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.61287
Abstract: APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression… read more here.
Keywords: expression; mechanism e2f; cancer; e2f pathway ... See more keywords