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   Articles with "e2f target" as a keyword



Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

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recommendations! Published in 2017 at "Cell Reports"

DOI: 10.1016/j.celrep.2017.05.053

Abstract: Summary The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major… read more here.

Keywords: target genes; tumor suppressor; prb; suppressor protein ... See more keywords

O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-61022-7

Abstract: The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated expression of the transcription factor… read more here.

Keywords: e2f pathway; foxk1; glcnacylation; e2f target ... See more keywords

MEOX2 mediates cisplatin resistance in ovarian cancer via E2F target and DNA repair pathways

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recommendations! Published in 2025 at "Journal of Ovarian Research"

DOI: 10.1186/s13048-025-01641-2

Abstract: Ovarian cancer (OV) is a leading cause of cancer-related mortality among women worldwide. Despite the success of platinum-based chemotherapy in treating OV, the emergence of cisplatin resistance has significantly compromised its therapeutic efficacy. Therefore, understanding… read more here.

Keywords: cisplatin resistance; resistance; e2f target; target dna ... See more keywords

A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.18587

Abstract: The average survival for patients with Pancreatic Ductal Adenocarcinoma (PDA) is merely 6 months, underscoring the need for new therapeutic approaches. During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that… read more here.

Keywords: bhlh activity; e2f target; pancreatic cancer; expression ... See more keywords