Contextual role of E2F1 in suppression of melanoma cell motility and invasiveness
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23043
Abstract: The general transcription factor E2F1 reportedly functions in a protumorigenic manner in several cancer models. We show that the genetic context of cancer cells influence E2F1's role to impede the protumorigenic role. Thirty to fifty… read more here.
Keywords: melanoma; oncogenic braf; e2f1; brafv600e ... See more keywords
Metastasis is altered through multiple processes regulated by the E2F1 transcription factor
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88924-y
Abstract: The E2F family of transcription factors is important for many cellular processes, from their canonical role in cell cycle regulation to other roles in angiogenesis and metastasis. Alteration of the Rb/E2F pathway occurs in various… read more here.
Keywords: transcription; etiology; metastasis altered; e2f1 ... See more keywords
The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10385-8
Abstract: Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant response. Here, the role of TRPM2 in cell… read more here.
Keywords: cell survival; trpm2; foxm1; e2f1 ... See more keywords
Translational control of E2f1 regulates the Drosophila cell cycle
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113704119
Abstract: Significance Here, we explore a mechanism wherein the growth signaling-dependent translation of mRNA encoding a cell cycle regulatory factor limits rates of cell proliferation. An essential cell cycle transcription factor, E2F1, was found to be… read more here.
Keywords: translation; cell cycle; e2f1; proliferation ... See more keywords
Regulation of the transcription factor E2F1 mRNA in ovarian granulosa cells of cattle.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of animal science"
DOI: 10.1093/jas/skz376
Abstract: The E2F family of transcription factors plays an important role in the control of the cell cycle, cell proliferation, and differentiation, and their role in ovarian function is just emerging. Although some evidence suggests a… read more here.
Keywords: e2f1 mrna; follicle; fgf9; abundance ... See more keywords
E2F1 regulates miR-215-5p to aggravate paraquat-induced pulmonary fibrosis via repressing BMPR2 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac071
Abstract: Background Pulmonary fibrosis is considered to be an irreversible lung injury, which can be caused by paraquat (PQ) poisoning. MiRNAs have been demonstrated crucial roles in pulmonary fibrosis caused by numerous approaches including PQ induction.… read more here.
Keywords: expression; pulmonary fibrosis; induced pulmonary; e2f1 ... See more keywords
p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000307
Abstract: BACKGROUNDAND AIM Non-alcoholic fatty liver disease (NAFLD) is characterized by steatosis, hepatic inflammation, and fibrosis which can develop into non-alcoholic steatohepatitis (NASH). NAFLD/NASH patients have increased ductular reaction (DR) and biliary senescence. High fat/high cholesterol… read more here.
Keywords: igf signaling; biliary e2f1; e2f1 foxo1; e2f1 ... See more keywords
New relationship of E2F1 and BNIP3 with caveolin‐1 in lung cancer‐associated fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13408
Abstract: In recent years, studies have found that E2F1, a downstream effector of caveolin‐1 (Cav‐1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1‐MFN2 axis as a… read more here.
Keywords: associated fibroblasts; e2f1; caveolin; cancer ... See more keywords
Transcription Factor E2F1 Regulates the Expression of ADRB2
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2023/8210685
Abstract: Adrenergic beta-2-receptor (ADRB2) is highly expressed in various tissue cells, affecting the susceptibility, development, and drug efficacy of diseases such as bronchial asthma and malignant tumor. However, the transcriptional regulatory mechanism of the human ADRB2… read more here.
Keywords: expression; adrb2; adrb2 gene; human adrb2 ... See more keywords
Abstract IA03: Differential impact of RB pathway status on E2F1 reprogramming and disease progression in human prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2017-ia03
Abstract: The retinoblastoma tumor suppressor (RB) is mechanistically linked to suppression of E2F1-mediated cell cycle regulation. Abrogation of RB function is associated with poor clinical outcome across various tumor types, which frequently elicit a preference for… read more here.
Keywords: status; prostate cancer; e2f1; pathway ... See more keywords
Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3701-y
Abstract: BackgroundEpithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer (SCLC). Our previous reports showed… read more here.
Keywords: zeb2; e2f1 promotes; e2f1; expression ... See more keywords