E2F2(E2F transcription factor 2) as a potential therapeutic target in meibomian gland carcinoma: evidence from functional and epigenetic studies
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DOI: 10.1186/s12885-025-13833-6
Abstract: Meibomian Gland Carcinoma (MGC) is a highly malignant eyelid tumor with a poor prognosis. This study investigates the molecular mechanisms underlying MGC, focusing on the abnormal expression of E2F transcription factor 2 (E2F2), often observed… read more here.
Keywords: mgc cells; methylation; mgc; e2f2 expression ... See more keywords
Alteration of E2F2 Expression in Governing Endothelial Cell Senescence
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DOI: 10.3390/genes13091522
Abstract: Endothelial cell senescence has a vital implication for vascular dysfunction, leading to age-related cardiovascular disease, especially hypertension and atherosclerosis. E2F transcription factor 2 (E2F2) plays a critical role in cell proliferation, differentiation, and DNA damage… read more here.
Keywords: cell; e2f2 expression; senescence; endothelial cell ... See more keywords
Decreased E2F2 Expression Correlates with Poor Prognosis and Immune Infiltrates in Patients with Colorectal Cancer
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DOI: 10.7150/jca.61415
Abstract: Growing evidence has revealed that the E2F family of transcription factor 2 (E2F2) participates in the tumorigenesis and progression of various tumors, but its role in colorectal cancer (CRC) remains largely unknown. Herein, the aim… read more here.
Keywords: cancer; decreased e2f2; expression; e2f2 expression ... See more keywords