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   Articles with "e2f4" as a keyword



Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2044651

Abstract: ABSTRACT Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a… read more here.

Keywords: zinc; e2f4; zinc homeostasis; cancer ... See more keywords

Dexamethasone Targets E2F4 to Induce Erythroid Progenitor Renewal

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-211687

Abstract: Corticosteroids such as dexamethasone (Dex) are the first line of treatment to modulate erythroid output in patients with Diamond Blackfan Anemia (DBA), an inherited bone marrow failure syndrome characterized by ribosomal protein (RP) insufficiency. Dexamethasone… read more here.

Keywords: treatment; dex; e2f4; progenitor ... See more keywords

Aberrant promoter methylation status is associated with upregulation of the E2F4 gene in breast cancer

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recommendations! Published in 2018 at "Oncology Letters"

DOI: 10.3892/ol.2018.8382

Abstract: E2F4 is an important basal transcription factor with the potential to promote tumor growth. Its upregulation in various types of cancer has been linked to numerous genetic factors; however, the nature of the involvement of… read more here.

Keywords: methylation; methylation status; expression; e2f4 ... See more keywords

Cellular Id1 inhibits hepatitis B virus transcription by interacting with the novel covalently closed circular DNA-binding protein E2F4

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.62106

Abstract: Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), which required developing novel therapies targeting the inhibition of HBV transcription and replication due to current limited treatment options. We explored… read more here.

Keywords: hbv; transcription; hbv transcription; e2f4 ... See more keywords