Articles with "e2f8" as a keyword



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Cell cycle oscillators underlying orderly proteolysis of E2F8

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Published in 2020 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e19-12-0725

Abstract: E2F8 is a transcriptional repressor that antagonizes E2F1 at the crossroads of the cell cycle, apoptosis, and cancer. Previously, we discovered that E2F8 is a direct target of the APC/C ubiquitin ligase. Nevertheless, it remains… read more here.

Keywords: e2f8; proteolysis; cell; cycle oscillators ... See more keywords
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Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells

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Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.21552

Abstract: A target molecule responsible for cell cycle arrest by metformin was discovered using a gene chip array in lung cancer cells and the effect of metformin on E2F8 was assessed. The siRNA-mediated knockdown of E2F8… read more here.

Keywords: cancer cells; cell cycle; lung cancer; e2f8 ... See more keywords