Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.022
Abstract: Plasmacytoid dendritic cells (pDCs) play immunosuppressive roles in the tumor microenvironment. However, the molecular mechanisms underlying the recruitment and dysfunction of pDCs in the tumor microenvironment remain largely elusive, especially in hepatocellular carcinoma (HCC). In… read more here.
Keywords: hepatocellular carcinoma; hcc; eado; dendritic cells ... See more keywords
The adenosine pathway in immuno-oncology
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0382-2
Abstract: Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from such treatments. Over the past decade, remarkable progress has been made… read more here.
Keywords: antitumour immunity; eado; pathway; cancer ... See more keywords
The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1111369
Abstract: Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis. eATP is rapidly accumulated in the extracellular space following… read more here.
Keywords: purinergic receptors; adenosinergic machinery; machinery cancer; eado ... See more keywords