Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23464
Abstract: Microglia contribute to pathophysiology at all stages of multiple sclerosis. Colony‐stimulating factor‐1 (CSF1) is crucial for microglial proliferation and activation. In this study we measured the CSF1 levels and studied its cellular expression in the… read more here.
Keywords: mouse spinal; eae; expression; csf1 ... See more keywords
Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24235
Abstract: Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis… read more here.
Keywords: oxidation; eae; neuroinflammation; odc mitochondria ... See more keywords
Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7862-5_17
Abstract: Experimental autoimmune encephalomyelitis (EAE) is one of the most popular animal models of multiple sclerosis (MS). There are a number of EAE models, being actively induced EAE in strains such as C57Bl/6 mice very robust… read more here.
Keywords: encephalomyelitis eae; eae; autoimmune encephalomyelitis; experimental autoimmune ... See more keywords
Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9620-9
Abstract: Purinergic P2X receptors, when activated under pathological conditions, participate in induction of the inflammatory response and/or cell death. Both neuroinflammation and neurodegeneration represent hallmarks of multiple sclerosis (MS), an autoimmune disease of the central nervous… read more here.
Keywords: administration; expression claudin; eae; p2x7 receptor ... See more keywords
Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02497-5
Abstract: Inflammation, demyelination, glial activation, and oxidative damage are the most pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black pepper, possesses antioxidant, anti-inflammatory, and neuroprotective properties whose therapeutic potential has been… read more here.
Keywords: anti inflammatory; eae; piperine; autoimmune encephalomyelitis ... See more keywords
Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Neurobiology"
DOI: 10.1007/s12035-022-02737-2
Abstract: Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells, immune-mediated attack of the myelin sheath, neuroinflammation, and/or axonal/neuronal dysfunctions. Some drugs… read more here.
Keywords: multiple sclerosis; eae; mog eae; protein ... See more keywords
Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.06.014
Abstract: In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) autoaggressive CD4+ T cells cross the blood-brain barrier (BBB) and cause neuroinflammation. Therapeutic targeting of CD4+ T-cell trafficking into the CNS by blocking… read more here.
Keywords: jam; bbb; eae; adhesion molecule ... See more keywords
Sex differences in EAE reveal common and distinct cellular and molecular components.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104242
Abstract: Experimental autoimmune encephalomyelitis (EAE) is commonly used as an animal model for evaluating clinical, histological and immunological processes potentially relevant to the human disease multiple sclerosis (MS), for which the mode of disease induction remains… read more here.
Keywords: male female; sex differences; disease; eae ... See more keywords
Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2022.104500
Abstract: Multiple sclerosis (MS) was one of the major conditions causing neurological dysfunction and was an incurable progressive central nervous system disease. Experimental autoimmune encephalomyelitis (EAE) was the most commonly used experimental model of MS. Artemisinin… read more here.
Keywords: eae; tpn10466; th17 differentiation; disease ... See more keywords
NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2022.104515
Abstract: Multiple sclerosis disproportionally affects women. The present study was undertaken to determine whether NFAT5 contributed to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, and if it did, whether the impact… read more here.
Keywords: eae; experimental autoimmune; female mice; autoimmune encephalomyelitis ... See more keywords
CCAAT/Enhancer‐binding protein &bgr; promotes pathogenesis of EAE
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DOI: 10.1016/j.cyto.2017.01.005
Abstract: HIGHLIGHTSCebpb−/− mice are resistant to EAE.In vivo Th17 responses are impaired in absence of C/EBP&bgr;.Th17 differentiation is normal in APC‐free cultures.C/EBP&bgr; binds to the IL‐23R in myeloid and Th17 cells. ABSTRACT The CCAAT/Enhancer Binding Protein… read more here.
Keywords: ccaat enhancer; ebp bgr; bgr; eae ... See more keywords