Early Administration of Bosentan in High‐Risk COVID‐19 Outpatients at Risk of Sarcopenia: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13753
Abstract: Endothelial damage induces myofibrillar breakdown and muscle degradation in COVID‐19 infection. There is a relationship between increased endothelin‐1 synthesis and sarcopenia. We evaluated the preventive effect of early bosentan therapy as an endothelin receptor blocker… read more here.
Keywords: early administration; risk; high risk; administration bosentan ... See more keywords
Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS‐CoV‐2 infection: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26407
Abstract: As it has been shown that lopinavir (LPV) and hydroxychloroquine (HCQ) have in vitro activity against coronaviruses, they were used to treat COVID‐19 during the first wave of the epidemic in Lombardy, Italy. To compare… read more here.
Keywords: clinical course; treatment; early administration; lpv hcq ... See more keywords
512. Does Time From COVID-19 Symptom Onset to Administration of Anti-spike Protein Monoclonal Antibody Predict Response?
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab466.711
Abstract: Abstract Background Casirivimab/imdevimab is a monoclonal antibody (mAb) cocktail with emergency use authorization for mild-to-moderate coronavirus disease 2019 (Covid-19) in patients at high risk for severe disease progression and/or hospitalization. Little is known about the… read more here.
Keywords: monoclonal antibody; symptom onset; early administration; grant research ... See more keywords
Early Administration of N-acetylcysteine in the Treatment of Clove Oil Ingestion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1097/mpg.0000000000001988
Abstract: n the Western world, essential oils are the fourth leading cause of accidental ingestions (1). Clove oil, an essential oil, is used to I alleviate toothaches (1) via its analgesic component eugenol. Eugenol is metabolized… read more here.
Keywords: treatment; early administration; oil ingestion; clove oil ... See more keywords
Early administration of tofacitinib in COVID‐19 pneumonitis: An open randomised controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13898
Abstract: Controversies on sub‐populations most sensitive to therapy and the best timing of starting the treatment still surround the use of immunomodulatory drugs in COVID‐19. read more here.
Keywords: open randomised; early administration; covid pneumonitis; pneumonitis open ... See more keywords
Early administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0307407
Abstract: One of the most important components of sepsis management is hemodynamic restoration. If the target mean arterial pressure (MAP) is not obtained, the first recommendation is for volume expansion, and the second is for norepinephrine… read more here.
Keywords: early administration; administration norepinephrine; trial; within hours ... See more keywords
Early Administration of Vancomycin Inhibits Pulmonary Embolism by Remodeling Gut Microbiota
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13030537
Abstract: Pulmonary embolism (PE) is a common and potentially fatal condition in the emergency department, and early identification of modifiable risk factors for prevention and management is highly desirable. Although gut dysbiosis is associated with a… read more here.
Keywords: gut; gut microbiota; early administration; administration vancomycin ... See more keywords