Automated classification of early afterdepolarizations grades in FLIPR calcium assays.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.05.096
Abstract: The detection and classification of proarrhythmic phenotypes like early afterdepolarizations (EADs) is fundamental in the safety pharmacology assessment of developing drugs. Calcium flux analysis enables sensitive and high throughput in vitro assays to assess potential… read more here.
Keywords: early afterdepolarizations; calcium flux; calcium; classification ... See more keywords
Dynamical mechanism for generation of arrhythmogenic early afterdepolarizations in cardiac myocytes: Insights from in silico electrophysiological models.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.106.024402
Abstract: We analyze the dynamical mechanisms underlying the formation of arrhythmogenic early afterdepolarizations (EADs) in two mathematical models of cardiac cellular electrophysiology: the Sato et al. biophysically detailed model of a rabbit ventricular myocyte of dimension 27… read more here.
Keywords: dynamical mechanism; generation; arrhythmogenic early; early afterdepolarizations ... See more keywords
Alternating Early Afterdepolarizations Underlying Bradycardia-Dependent Macroscopic T Wave and Discordant Mechanical Alternans
Sign Up to like & getrecommendations! Published in 2023 at "Circulation: Arrhythmia and Electrophysiology"
DOI: 10.1161/circep.122.011453
Abstract: Background: Macroscopic T wave alternans (macro-TWA) often heralds the onset of Torsades de Pointes in patients with QT prolongation. However, the mechanisms underlying macro-TWA remain unclear. We examined the cellular and ionic basis for macro-TWA… read more here.
Keywords: alternating early; mechanical alternans; macroscopic wave; early afterdepolarizations ... See more keywords
Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008341
Abstract: The pumping of blood through the heart is due to a wave of muscle contractions that are in turn due to a wave of electrical activity initiated at the sinoatrial node. At the cellular level,… read more here.
Keywords: cardiac cells; size window; window region; early afterdepolarizations ... See more keywords
Early afterdepolarizations in cardiac action potentials as mixed mode oscillations due to a folded node singularity
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209498
Abstract: Early afterdepolarizations (EADs) are pathological voltage oscillations during the repolarization phase of cardiac action potentials. They are considered as potential precursors to cardiac arrhythmias and have recently gained much attention in the context of preclinical… read more here.
Keywords: mixed mode; folded node; cardiac action; early afterdepolarizations ... See more keywords