Lecanemab for Patients With Early Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.7230
Abstract: Key Points Question The US Food and Drug Administration has promoted innovation in clinical trial design via the bayesian approach; does that make clinical trials more efficient? Findings In this bayesian analysis of a randomized… read more here.
Keywords: patients early; alzheimer disease; lecanemab patients; early alzheimer ... See more keywords
The importance of sustained attention in early Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4537
Abstract: There is conflicting evidence regarding impairment of sustained attention in early Alzheimer's disease (AD). We examine whether sustained attention is impaired and predicts deficits in other cognitive domains in early AD. read more here.
Keywords: alzheimer disease; attention early; attention; early alzheimer ... See more keywords
Associations between cortical β‐amyloid burden, fornix microstructure and cognitive processing of faces, places, bodies and other visual objects in early Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23493
Abstract: Using two imaging modalities, that is, Pittsburgh compound B (PiB) positron emission tomography (PET) and diffusion tensor imaging (DTI) the present study tested associations between cortical amyloid‐beta (Aβ) burden and fornix microstructural changes with cognitive… read more here.
Keywords: early alzheimer; associations cortical; alzheimer disease; cortical amyloid ... See more keywords
Tilavonemab in early Alzheimer’s disease: results from a phase 2, randomized, double-blind study
Sign Up to like & getrecommendations! Published in 2023 at "Brain"
DOI: 10.1093/brain/awad024
Abstract: Abstract Tau accumulation in patients with Alzheimer’s disease tracks closely with cognitive decline and plays a role in the later stages of disease progression. This phase 2 study evaluated the safety and efficacy of tilavonemab,… read more here.
Keywords: early alzheimer; disease; alzheimer disease; randomized double ... See more keywords
Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid‐β peptide exposure
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15575
Abstract: Amyloid‐β peptides (Aβ) accumulate in the brain since early Alzheimer's disease (AD) and dysregulate hippocampal synaptic plasticity, the neurophysiological basis of memory. Although the relationship between long‐term potentiation (LTP) and memory processes is well established,… read more here.
Keywords: early alzheimer; alzheimer disease; ltd; hippocampal synaptic ... See more keywords