Early Antibiotic Discontinuation in Pediatric Suspected Septic Arthritis with No Pathogen Identified: Results of a 6-Year Protocol-Based Observational Study.
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DOI: 10.1093/jpids/piaf080
Abstract: In a 6-year observational study of 45 children with suspected septic arthritis and no pathogen identified, early antibiotic discontinuation based on strict clinical and biological criteria was not associated with relapse during the six-month period… read more here.
Keywords: observational study; pathogen identified; septic arthritis; early antibiotic ... See more keywords
Early antibiotic use and incidence of necrotising enterocolitis in very preterm infants: a protocol for a UK based observational study using routinely recorded data
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DOI: 10.1136/bmjopen-2022-065934
Abstract: Introduction Necrotising enterocolitis (NEC) remains a major contributor to preterm mortality and morbidity. Prolonged duration of antibiotic therapy after delivery is associated with later NEC development but recent evidence suggests that absence of antibiotic treatment… read more here.
Keywords: early antibiotic; necrotising enterocolitis; preterm infants; use ... See more keywords
Reductions in hospitalisations and emergency department visits with early antibiotic initiation in nontuberculous mycobacterial lung disease
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DOI: 10.1183/23120541.00963-2023
Abstract: Background While antibiotics are recommended for treatment of nontuberculous mycobacterial lung disease (NTMLD), the impact of early antibiotic initiation on healthcare resource utilisation is unclear. This study compared healthcare resource utilisation with early versus delayed… read more here.
Keywords: antibiotic initiation; initiation; nontuberculous mycobacterial; delayed antibiotic ... See more keywords
Diagnostic Accuracy of Presepsin and Its Impact on Early Antibiotic De-Escalation in Burn-Related Sepsis
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DOI: 10.3390/antibiotics14080822
Abstract: Background/Objectives: Despite overlapping inflammatory responses and frequent culture-negative results in severe burn patients, early and accurate sepsis diagnosis remains challenging. We aimed to evaluate the diagnostic performance of seven candidate biomarkers and their clinical utility,… read more here.
Keywords: culture negative; culture; early antibiotic; diagnostic accuracy ... See more keywords