Estimation of the treatment effect following a clinical trial that stopped early for benefit
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DOI: 10.1177/09622802221122445
Abstract: When a clinical trial stops early for benefit, the maximum likelihood estimate (MLE) of the treatment effect may be subject to overestimation bias. Several authors have proposed adjusting for this bias using the conditional MLE,… read more here.
Keywords: treatment effect; early benefit; mle; trial ... See more keywords