Protective mechanism of FoxO1 against early brain injury after subarachnoid hemorrhage by regulating autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Brain and behavior"
DOI: 10.1002/brb3.2376
Abstract: INTRODUCTION Early brain injury (EBI) plays a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). Autophagy and apoptosis may share a common molecular inducer that regulates the process of cell death. FoxO1, as… read more here.
Keywords: early brain; foxo1; brain; function ... See more keywords
Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00571-w
Abstract: Paeoniflorin is a natural monoterpene glucoside from Paeoniae Radix with neuroprotective properties. However, it is still unclear whether paeoniflorin has neuroprotective effects on subarachnoid hemorrhage (SAH). This study explores the effect of paeoniflorin on early… read more here.
Keywords: early brain; subarachnoid hemorrhage; brain injury; brain ... See more keywords
Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-018-0232-8
Abstract: Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage (SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates… read more here.
Keywords: fluoxetine neuroprotective; early brain; subarachnoid hemorrhage; brain ... See more keywords
Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.081
Abstract: The subversive role of Calcium sensing receptor (CaSR) in cerebral ischemia and traumatic brain injury has been recently reported. Nevertheless, the role of CaSR in early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains unexplored.… read more here.
Keywords: early brain; camkii; brain injury; brain ... See more keywords
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134979
Abstract: BACKGROUND Sphingosine kinase (SphK) 1 has been reported as an important signaling node in anti-apoptotic signaling. Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated if heparin prevents early… read more here.
Keywords: low dose; early brain; subarachnoid hemorrhage; heparin posttreatment ... See more keywords
A review on neuroimaging studies of genetic and environmental influences on early brain development
Sign Up to like & getrecommendations! Published in 2019 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2018.04.032
Abstract: &NA; The past decades witnessed a surge of interest in neuroimaging study of normal and abnormal early brain development. Structural and functional studies of normal early brain development revealed massive structural maturation as well as… read more here.
Keywords: early brain; studies genetic; genetic environmental; brain development ... See more keywords
A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00525-w
Abstract: Longitudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the rapid change in size, shape and volume of the developing brain, and the consequent lack of… read more here.
Keywords: fetal brain; brain growth; analysis; early brain ... See more keywords
Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2037227
Abstract: ABSTRACT Subarachnoid hemorrhage (SAH) is a severe brain condition associated with a significantly high incidence and mortality. As a consequence of SAH, early brain injury (EBI) may contribute to poor SAH patient outcomes. Apoptosis is… read more here.
Keywords: signaling pathway; early brain; fluoxetine; brain injury ... See more keywords
The poly-ADP ribose polymerase-1/apoptosis-inducing factor pathway may help mediate the protective effect of electroacupuncture on early brain injury after subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001445
Abstract: Subarachnoid hemorrhage (SAH) is a clinically common, acute, critical cerebrovascular disease associated with high mortality. Here, we investigated the effects of electroacupuncture on early brain injury after SAH. We successfully established a Sprague–Dawley rat model… read more here.
Keywords: early brain; electroacupuncture; apoptosis; brain injury ... See more keywords
Ponesimod protects against neuronal death by suppressing the activation of A1 astrocytes in early brain injury after experimental subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15457
Abstract: As an important initiator and responder of brain inflammation in the central nervous system (CNS), astrocytes transform into two new reactive phenotypes with changed morphology, altered gene expression and secretion profiles, termed detrimental A1 and… read more here.
Keywords: ponesimod; early brain; subarachnoid hemorrhage; brain injury ... See more keywords
Impact of surgery and anesthesia during early brain development: a perfect storm.
Sign Up to like & getrecommendations! Published in 2022 at "Paediatric anaesthesia"
DOI: 10.1111/pan.14433
Abstract: Neonatal surgery and concomitant anesthesia coincide with a timeframe of rapid brain development. The speed and complexity of early brain development superimposed on immature regulatory mechanisms that include incomplete cerebral autoregulation, insufficient free radical scavenging… read more here.
Keywords: early brain; neonatal surgery; surgery; brain ... See more keywords