Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.142514
Abstract: BACKGROUND Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction.… read more here.
Keywords: 18f thk5351; cortical excitability; excitability; brainstem ... See more keywords
Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.344838
Abstract: [INLINE:1] According to clinical statistics, the mortality of patients with early brainstem hemorrhage is high. In this study, we established rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine… read more here.
Keywords: brainstem hemorrhage; histopathology; multi sequence; early brainstem ... See more keywords