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   Articles with "early cell" as a keyword



Integrated clinical genotype‐phenotype characteristics of early T‐cell precursor acute lymphoblastic leukemia

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recommendations! Published in 2022 at "Cancer"

DOI: 10.1002/cncr.34515

Abstract: Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a distinct subtype of T‐ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP‐ALL patients are poorly… read more here.

Keywords: cell precursor; precursor acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords

Conditional deletion of mTOR discloses its essential role in early B‐cell development

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recommendations! Published in 2021 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23386

Abstract: Mechanistic target of rapamycin (mTOR) is a serine‐threonine kinase and central regulator of cell growth, differentiation, and survival. mTOR is commonly hyperactivated in a diverse number of cancers and critical roles for mTOR in regulating… read more here.

Keywords: early cell; cell development; cell; essential role ... See more keywords

Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions

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recommendations! Published in 2018 at "iScience"

DOI: 10.1016/j.isci.2018.08.015

Abstract: Summary The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by the field. Cell seeding densities of 1,000 to 100,000… read more here.

Keywords: single cell; breast; early cell; sphere formation ... See more keywords

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.

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recommendations! Published in 2021 at "Cell death and differentiation"

DOI: 10.1038/s41418-021-00906-9

Abstract: In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of the signaling complex from complex-I to death-inducing complex-II. Here, we report that ankyrin repeat domain 13a (ANKRD13a)… read more here.

Keywords: early cell; cell death; death; death checkpoint ... See more keywords

Clinical and molecular characterization of early T-cell precursor acute lymphoblastic leukemia

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recommendations! Published in 2018 at "Medicine"

DOI: 10.1097/md.0000000000013856

Abstract: Rationale: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a small subtype of T-cell acute lymphoblastic leukemia with a typical immune-phenotype: lack of T-lineage cell surface markers CD1a and CD8 expression, weak or absent CD5… read more here.

Keywords: early cell; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords

The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments.

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recommendations! Published in 2023 at "Aging cell"

DOI: 10.1111/acel.13870

Abstract: Age-related thymus involution results in decreased T-cell production, contributing to increased susceptibility to pathogens and reduced vaccine responsiveness. Elucidating mechanisms underlying thymus involution will inform strategies to restore thymopoiesis with age. The thymus is colonized… read more here.

Keywords: cell; bone marrow; thymus; age ... See more keywords

Neutrophil count is an independent prognostic indicator in early T-cell precursor lymphoblastic leukemia

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-6892

Abstract: Purpose Early T-cell precursor lymphoblastic leukemia (ETP-ALL) is an immunophenotypically defined subgroup of T-ALL associated with poor prognosis. However, emerging studies indicate that the prognosis of ETP-ALL is not inferior to that of non-ETP-ALL, underscoring… read more here.

Keywords: cell precursor; etp; count; early cell ... See more keywords

Transcriptomic analysis of early B-cell development in the chicken embryo

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recommendations! Published in 2019 at "Poultry Science"

DOI: 10.3382/ps/pez354

Abstract: ABSTRACT The chicken bursa of Fabricius is a primary lymphoid tissue important for B-cell development. Our long-term goal is to understand the role of bursal microenvironment in an early B-cell differentiation event initiating repertoire development… read more here.

Keywords: cell development; early cell; transcriptomic analysis; cell ... See more keywords

Potential Regulatory Effect of mir-182-3p on Osteosarcoma by Targeting Early B-Cell Factor 2

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recommendations! Published in 2020 at "Indian Journal of Pharmaceutical Sciences"

DOI: 10.36468/pharmaceutical-sciences.spl.115

Abstract: This study investigated the role of miR-182-3p in osteosarcoma. The effect of the miR-182-3p expression on cell function and the regulatory signal changes of Early B-cell Factor 2 targeted by miR-182-3p were studied in the… read more here.

Keywords: early cell; mir 182; osteosarcoma; cell factor ... See more keywords