Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00410
Abstract: The use of biocatalysis in the manufacture of small molecule active pharmaceutical ingredients has seen a marked increase over the past decade. Driven by academic and industrial interest in the application of enzymes as catalysts… read more here.
Keywords: early discovery; medicinal chemistry; chemistry; adoption biocatalysis ... See more keywords
Assessing developability early in the discovery process for novel biologics
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2171248
Abstract: ABSTRACT Beyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures.… read more here.
Keywords: discovery process; developability early; early discovery; assessing developability ... See more keywords