Recent advances in metabolomics analysis for early drug development.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.02.018
Abstract: The pharmaceutical industry adapted proteomics and other 'omics technologies for drug research early following their initial introduction. Although metabolomics lacked behind in this development, it has now become an accepted and widely applied approach in… read more here.
Keywords: development; early drug; drug; metabolomics analysis ... See more keywords
Proposal of a Parameter for OATP1B1 Inhibition Screening at the early Drug Discovery Stage.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.08.012
Abstract: It is known that potent inhibition of organic anion transporting polypeptide (OATP)1B1 increases exposure to statins, leading to severe adverse effects. The aim of this study is to propose a parameter and its criteria in… read more here.
Keywords: drug; oatp1b1 inhibition; early drug; stage ... See more keywords
XenoSarc: A comprehensive platform of patient-derived xenograft (PDX) models of soft tissue sarcoma (STS) for early drug testing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Global Oncology"
DOI: 10.1200/jgo.2019.5.suppl.37
Abstract: 37 Background: STS is a family of rare, heterogeneous tumors with > 70 subtypes. There is an urgent need for reliable preclinical models, especially for orphan subtypes of STS, given the limited treatment options. Methods:… read more here.
Keywords: sarcoma; drug testing; pdx models; tissue ... See more keywords
Unveiling changes in the landscape of patient populations in cancer early drug development
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DOI: 10.18632/oncotarget.13258
Abstract: The introduction of new Molecularly Targeted Agents (MTA) has changed the landscape in Early Drug Development (EDD) over the last two decades, leading to an improvement in clinical trial design. Previous Phase 1 (Ph1) studies… read more here.
Keywords: early drug; drug development; patient populations; cancer ... See more keywords
QT Assessment in Early Drug Development: The Long and the Short of It
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20061324
Abstract: The QT interval occupies a pivotal role in drug development as a surface biomarker of ventricular repolarization. The electrophysiologic substrate for QT prolongation coupled with reports of non-cardiac drugs producing lethal arrhythmias captured worldwide attention… read more here.
Keywords: drug development; assessment early; drug; arrhythmias ... See more keywords
Preclinical Models of Nontuberculous Mycobacteria Infection for Early Drug Discovery and Vaccine Research
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9080641
Abstract: Nontuberculous mycobacteria (NTM) represent an increasingly prevalent etiology of soft tissue infections in animals and humans. NTM are widely distributed in the environment and while, for the most part, they behave as saprophytic organisms, in… read more here.
Keywords: nontuberculous mycobacteria; drug; early drug; discovery vaccine ... See more keywords