Gene mutations impede oocyte maturation, fertilization, and early embryonic development
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200007
Abstract: Reproductive diseases are a long‐standing problem and have become more common in the world. Currently, 15% of the world's population suffers from infertility, and half of them are women. Maturation of oocytes, successful fertilization, and… read more here.
Keywords: maturation; fertilization; development; oocyte maturation ... See more keywords
Involvement of Early Embryonic miR-409-3p in the Establishment of Anxiety Levels in Female Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental neurobiology"
DOI: 10.1002/dneu.22756
Abstract: Small RNA molecules in early embryos delivered from sperm to zygotes upon fertilization are required for normal mouse embryonic development and even modest changes in the levels of sperm-derived miRNAs appear to influence early embryos… read more here.
Keywords: anxiety; mir 409; mice; early embryonic ... See more keywords
Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24448
Abstract: The subcortical maternal complex (SCMC), composed of several maternal‐effect genes, is vital for the development of oocytes and early embryos. Variants of SCMC‐encoding genes (NLRP2, NLRP5, TLE6, PADI6, and KHDC3L, but not OOEP and ZBED3)… read more here.
Keywords: arrest; nlrp5 identified; mutations ooep; ooep nlrp5 ... See more keywords
Inducing somatic cells into pluripotent stem cells is an important platform to study the mechanism of early embryonic development
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23559
Abstract: The early embryonic development starts with the totipotent zygote upon fertilization of differentiated sperm and egg, which undergoes a range of reprogramming and transformation to acquire pluripotency. Induced pluripotent stem cells (iPSCs), a nonclonal technique… read more here.
Keywords: development; embryonic development; early embryonic; stem cells ... See more keywords
High-throughput transcriptome-Seq and small RNA-Seq reveal novel functional genes and microRNAs for early embryonic arrest in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.12.084
Abstract: Early Embryonic Arrest (EEA) is one of the major causes of female infertility. Genetic factors including specific genes and miRNAs may play pivotal roles on EEA. However, it is not well defined what genes and… read more here.
Keywords: seq; embryonic arrest; gene; early embryonic ... See more keywords
A Hypothesis: Retrotransposons as a Relay of Epigenetic Marks in Intergenerational Epigenetic Inheritance.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146229
Abstract: Epigenetic marks in gametes, which both respond to the parental environmental factors and shape offspring phenotypes, are usually positioned to mediate intergenerational or transgenerational epigenetic inheritance. Nonetheless, the mechanisms through which gametic epigenetic signatures encode… read more here.
Keywords: epigenetic inheritance; embryonic development; early embryonic; gametic epigenetic ... See more keywords
Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague‐Dawley rats
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.10.008
Abstract: ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) have developed as novel antidepressants and have been determined to possess higher efficacy and less adverse effects compared to other antidepressants. Our previous studies have showed that LPM570065, a… read more here.
Keywords: male rats; embryonic development; fertility early; early embryonic ... See more keywords
Bovine Sperm Sexing Alters Sperm Morphokinetics and Subsequent Early Embryonic Development
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63077-6
Abstract: In artificial insemination the use of sex-sorted bovine sperm results in reduced conception, the causes of which are only partly understood. Therefore, we set out to investigate the effects of sexing on bovine sperm function… read more here.
Keywords: bovine sperm; sexed sperm; embryonic development; sperm ... See more keywords
102 A delay in maternal zygotic transition may lead to early embryonic loss in poor-quality bovine blastocysts
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv32n2ab102
Abstract: Increased genetic potential and performance of dairy cows has coincided with a decline in fertility. Early embryonic mortality accounts for 75-80% of this decline in fertility, costing the industry over $1.28 trillion worldwide. Despite advancements… read more here.
Keywords: quality; poor quality; embryo mortality; maternal zygotic ... See more keywords
Endo-siRNAs regulate early embryonic development by inhibiting transcription of long terminal repeat sequence in pig†
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz042
Abstract: Abstract Activity of some endogenous retroviruses (ERVs) has been proven to be important for development of early mammalian embryo. However, abnormal activation of ERVs can also cause genetic diseases due to their ability to retrotranspose,… read more here.
Keywords: pig; embryonic development; long terminal; endo sirnas ... See more keywords
Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz235
Abstract: Abstract Characterization of the molecular factors regulating early embryonic development and their functional mechanisms is critical for understanding the causes of early pregnancy loss in monotocous species (cattle, human). We previously characterized a stage specific… read more here.
Keywords: embryotropic actions; follistatin; embryonic development; stage specific ... See more keywords