Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
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DOI: 10.1038/s41598-019-42298-4
Abstract: Unconventional protein secretion represents an important process of the inflammatory response. The release of the pro-inflammatory cytokine interleukin (IL)-1β which burst during pyroptosis as a consequence of gasdermin D plasma membrane pore formation, can also… read more here.
Keywords: caspase; caspase activation; early endosome; endosome autoantigen ... See more keywords
A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy
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DOI: 10.1080/15548627.2022.2040314
Abstract: ABSTRACT NLRP3 (NLR family pyrin domain containing 3) inflammasome is a potent mediator of inflammation due to its ability to produce the pro-inflammatory cytokines IL1B (interleukin 1 beta) and IL18 in response to numerous danger… read more here.
Keywords: new role; early endosome; inflammasome activation; role early ... See more keywords
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
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DOI: 10.26508/lsa.201900439
Abstract: This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis. Shiga toxin 1 (STx1) and 2 (STx2),… read more here.
Keywords: trafficking shiga; early endosome; toxin; shiga toxin ... See more keywords