Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.11.023
Abstract: Summary Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early… read more here.
Keywords: integration gpcr; signaling sorting; gpcr signaling; gpcr ... See more keywords
A method for quantification of vesicular compartments within cells using 3D reconstructed confocal z-stacks: Comparison of ImageJ and Imaris to count early endosomes within basal forebrain cholinergic neurons
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2020.109038
Abstract: BACKGROUND Phenotypic changes in vesicular compartments are an early pathological hallmark of many peripheral and central diseases. For example, accurate assessment of early endosome pathology is crucial to the study of Down syndrome (DS) and… read more here.
Keywords: microscopy; pathology; early endosomes; endosomes within ... See more keywords
Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2015.87
Abstract: The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In… read more here.
Keywords: mediated internalization; human langerhans; cross; early endosomes ... See more keywords
Preprint Highlight: The novel Rab5 effector FERRY links early endosomes with the translation machinery.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-04-1001
Abstract: Early endosomes bind certain mRNAs and are thought to facilitate translation thereon, but the mechanism underlying this function is not known. This study identifies a novel Rab 5 effector complex, the five-subunit endosomal Rab5 and… read more here.
Keywords: preprint highlight; highlight novel; novel rab5; early endosomes ... See more keywords
Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage (Adv. Sci. 13/2023)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1101/2022.11.02.514845
Abstract: The plasma membrane of a cell is subject to stresses causing ruptures that must be repaired immediately to preserve membrane integrity and ensure cell survival. Yet, the spatio-temporal membrane dynamics at the wound site and… read more here.
Keywords: exocytosis; damage; early endosomes; membrane ... See more keywords
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259138
Abstract: ABSTRACT Cell migration is a complex process underlying physiological and pathological processes such as brain development and cancer metastasis. The autophagy-linked FYVE protein (ALFY; also known as WDFY3), an autophagy adaptor protein known to promote… read more here.
Keywords: cell; early endosomes; alfy localizes; migration ... See more keywords
Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201642738
Abstract: The mechanisms driving pathological beta‐amyloid (Aβ) generation in late‐onset Alzheimer's disease (AD) are unclear. Two late‐onset AD risk factors, Bin1 and CD2AP, are regulators of endocytic trafficking, but it is unclear how their endocytic function… read more here.
Keywords: generation; early endosomes; bin1 cd2ap; beta amyloid ... See more keywords
Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling
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DOI: 10.15252/embr.201947734
Abstract: Despite recently uncovered connections between autophagy and the endocytic pathway, the role of autophagy in regulating endosomal function remains incompletely understood. Here, we find that the ablation of autophagy‐essential players disrupts EGF‐induced endocytic trafficking of… read more here.
Keywords: autophagy facilitates; targeting early; endosomes autophagy; early endosomes ... See more keywords
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Reports"
DOI: 10.15252/embr.202254701
Abstract: Transmembrane proteins are internalized by clathrin‐ and caveolin‐dependent endocytosis. Both pathways converge on early endosomes and are thought to share the small GTPase Rab5 as common regulator. In contrast to this notion, we show here… read more here.
Keywords: rab21; mediated endocytic; caveolin mediated; early endosomes ... See more keywords
The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.634003
Abstract: Lymphocyte homeostasis, activation and differentiation crucially rely on basal autophagy. The fine-tuning of this process depends on autophagy-related (ATG) proteins and their interaction with the trafficking machinery that orchestrates the membrane rearrangements leading to autophagosome… read more here.
Keywords: atg16l1 early; endosomes promote; intraflagellar transport; early endosomes ... See more keywords
On the entry of an emerging arbovirus into host cells: Mayaro virus takes the highway to the cytoplasm through fusion with early endosomes and caveolae-derived vesicles
Sign Up to like & getrecommendations! Published in 2017 at "PeerJ"
DOI: 10.7717/peerj.3245
Abstract: Mayaro virus (MAYV) is an emergent sylvatic alphavirus in South America, related to sporadic outbreaks of a chikungunya-like human febrile illness accompanied by severe arthralgia. Despite its high potential for urban emergence, MAYV is still… read more here.
Keywords: caveolae derived; mayaro virus; derived vesicles; early endosomes ... See more keywords