Pluripotent stem cell models of early mammalian development.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.05.010
Abstract: Pluripotent stem cells derived from the early mammalian embryo offer a convenient model system for studying cell fate decisions in embryogenesis. The last 10 years have seen a boom in the popularity of two-dimensional micropatterns… read more here.
Keywords: stem cell; pluripotent stem; early mammalian; cell ... See more keywords
Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.02.024
Abstract: Research in developmental biology has been recently enriched by a multitude of in vitro models recapitulating key milestones of mammalian embryogenesis. These models obviate the challenge posed by the inaccessibility of implanted embryos, multiply experimental opportunities,… read more here.
Keywords: mammalian development; understanding mechanobiology; mechanobiology early; development bioengineered ... See more keywords
Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.10.008
Abstract: Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in remodeling of the epigenomes can cause severe developmental defects, including embryonic lethality. However,… read more here.
Keywords: mammalian development; development inheritance; inheritance reprogramming; epigenome early ... See more keywords
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04155-2
Abstract: A fundamental question in developmental and stem cell biology concerns the origin and nature of signals that initiate asymmetry leading to pattern formation and self-organization. Instead of having prominent pre-patterning determinants as present in model… read more here.
Keywords: pattern formation; tracing origin; origin heterogeneity; mammalian embryo ... See more keywords
Initial source of heterogeneity in a model for cell fate decision in the early mammalian embryo
Sign Up to like & getrecommendations! Published in 2022 at "Interface Focus"
DOI: 10.1098/rsfs.2022.0010
Abstract: During development, cells from a population of common progenitors evolve towards different fates characterized by distinct levels of specific transcription factors, a process known as cell differentiation. This evolution is governed by gene regulatory networks… read more here.
Keywords: cell fate; cell; heterogeneity; source ... See more keywords
Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.708318
Abstract: The energetically costly mammalian investment in gestation and lactation requires plentiful nutritional sources and thus links the environmental conditions to reproductive success. Flexibility in adjusting developmental timing enhances chances of survival in adverse conditions. Over… read more here.
Keywords: early mammalian; molecular regulation; stem cells; mammalian embryos ... See more keywords
Checkpoint Kinase 1 Is a Key Signal Transducer of DNA Damage in the Early Mammalian Cleavage Embryo
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076778
Abstract: After fertilization, remodeling of the oocyte and sperm genome is essential for the successful initiation of mitotic activity in the fertilized oocyte and subsequent proliferative activity of the early embryo. Despite the fact that the… read more here.
Keywords: cleavage; dna; checkpoint kinase; kinase key ... See more keywords