Ascorbic acid increases SVCT2 localization at the plasma membrane by accelerating its trafficking from early secretory compartments and through the endocytic‐recycling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.03.013
Abstract: ABSTRACT Ascorbic acid (Asc) is an antioxidant molecule essential for physiological functions. The concentration of extracellular Asc increases during synaptic transmission and renal reabsorption. These phenomena induce an increase of the Sodium‐dependent‐Vitamin‐C‐transporter 2 (SVCT2) at… read more here.
Keywords: response; ascorbic acid; acute response; early secretory ... See more keywords
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08429-1
Abstract: Zinc ions (Zn2+) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood. Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone… read more here.
Keywords: secretory pathway; zn2; protein quality; early secretory ... See more keywords
Epithelial sodium channel biogenesis and quality control in the early secretory pathway
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000438
Abstract: Purpose of review The epithelial sodium channel, ENaC, is responsible for Na+ reabsorption in several epithelia and is composed of homologous &agr;, &bgr;, and &ggr; subunits. Here, we will explore the differential regulation of ENaC… read more here.
Keywords: secretory pathway; sodium; channel; early secretory ... See more keywords
Early Secretory Pathway-Associated Proteins SsEmp24 and SsErv25 Are Involved in Morphogenesis and Pathogenicity in a Filamentous Phytopathogenic Fungus
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DOI: 10.1128/mbio.03173-21
Abstract: Understanding the reproduction and pathogenesis mechanism of phytopathogens could provide new opinions to effectively control fungal diseases. Although it has been known that effectors and extracellular hydrolytic enzymes secreted by phytopathogenic fungi play important roles… read more here.
Keywords: early secretory; phytopathogenic fungi; secretion; secretory pathway ... See more keywords
Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1069256
Abstract: The conventional early secretory pathway and autophagy are two essential interconnected cellular processes that are crucial for maintaining cellular homeostasis. The conventional secretory pathway is an anabolic cellular process synthesizing and delivering proteins to distinct… read more here.
Keywords: cellular homeostasis; pathway autophagy; conventional early; early secretory ... See more keywords
Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.803302
Abstract: Biallelic pathogenic variants in TBCK cause encephaloneuropathy, infantile hypotonia with psychomotor retardation, and characteristic facies 3 (IHPRF3). The molecular mechanisms underlying its neuronal phenotype are largely unexplored. In this study, we reported two sisters, who… read more here.
Keywords: vesicle transport; neuroprogenitor cells; transport; secretory ... See more keywords