Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial
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DOI: 10.1093/cid/ciw862
Abstract: Background Patients coinfected with syphilis and human immunodeficiency virus (HIV) may have a slower decrease in rapid plasma reagin (RPR) titers. Currently a single dose of 2.4 million units of intramuscular benzathine penicillin G (BPG)… read more here.
Keywords: early syphilis; treatment; hiv; dose ... See more keywords
Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky006
Abstract: Background Some syphilitic patients remain in a serologically positive state after the recommended therapy. Although we often retreat patients in clinical practice, the optimal treatment protocol remains uncertain due to the paucity of data regarding… read more here.
Keywords: early syphilis; retreatment; serological response; therapy ... See more keywords
Characteristics of the Largest Network Component of Individuals with or exposed to Early Syphilis in Central Indiana: 2016-2017.
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DOI: 10.1097/olq.0000000000001289
Abstract: BACKGROUND The surge of syphilis infections in the United States continues. This study examined the sexual networks of early syphilis cases to determine whether repeat infection, demographics, or behaviors differed among network components (groups of… read more here.
Keywords: central indiana; early syphilis; network; main component ... See more keywords
Coinfection With Chlamydial and Gonorrheal Infection Among US Adults With Early Syphilis
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DOI: 10.1097/olq.0000000000001605
Abstract: Among 865 US adults with early syphilis, more than 1 in 4 had bacterial STI coinfection. This study supports routine mucosal screening for chlamydia and gonorrhea in people with syphilis. Abstract Among 865 adults with… read more here.
Keywords: early syphilis; sexually transmitted; infection; adults early ... See more keywords
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study
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DOI: 10.1136/sextrans-2016-052938
Abstract: Objective To determine the prevalence of asymptomatic neurosyphilis (ANS) in HIV-positive individuals after treatment of early syphilis with single-dose benzathine penicillin G (BPG) or oral antibiotic alternatives. Methods Patients at high risk of neurosyphilis (defined… read more here.
Keywords: early syphilis; syphilis; treatment; csf ... See more keywords
P2.48 Molecular subtyping of treponema pallidum and associated factors of serofast status in early syphilis patients: identified novel genotype and cytokine marker
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DOI: 10.1136/sextrans-2017-053264.224
Abstract: Introduction Serofast remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. Methods Between August 2011 and July 2015, eligible patients… read more here.
Keywords: early syphilis; syphilis patients; cytokine marker; serofast status ... See more keywords
P771 Clinical trial of cefixime for the treatment of early syphilis – preliminary results
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DOI: 10.1136/sextrans-2019-sti.829
Abstract: Background Increasing incidence of syphilis in the United States and penicillin shortages internationally call for research on alternative treatment options. In this randomized, multisite, open-label, non-comparative clinical trial, we are evaluating the efficacy of cefixime… read more here.
Keywords: clinical trial; early syphilis; treatment; cefixime ... See more keywords
Transitioning HIV-negative men who have sex with men and transgender women diagnosed with early syphilis to HIV-pre-exposure prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2023-055854
Abstract: Identifying individuals with early syphilis who would benefit from HIVpreexposure prophylaxis (HIVPrEP) is important to reduce HIV transmission. 2 There were 171 individuals diagnosed with early syphilis in our clinic between July 2021 and June… read more here.
Keywords: diagnosed early; early syphilis; prophylaxis; transgender women ... See more keywords
Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China
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DOI: 10.1371/journal.pone.0245812
Abstract: Background Syphilis is a common infectious disease worldwide. Serological monitoring is important for syphilis management. We currently know little about the characteristics of this seronegative response. The aim of this study was to explore the… read more here.
Keywords: patients early; early syphilis; serological cure; cure ... See more keywords
Predictors of serological cure after treatment in patients with early syphilis: A retrospective observational study in Thailand.
Sign Up to like & getrecommendations! Published in 2019 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.4103/ijdvl.ijdvl_810_17
Abstract: Background Some patients with early syphilis who receive appropriate treatment do not reach a serological cure and have a persistent titer which does not meet the criteria for treatment failure (serofast state). Aims This retrospective… read more here.
Keywords: patients early; treatment; early syphilis; serofast state ... See more keywords