Design of Light‐Activated Nanoplatform through Boosting “Eat Me” Signals for Improved CD47‐Blocking Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102712
Abstract: Here, the authors propose a light‐activated reactive oxygen species (ROS)‐responsive nanoplatform that can boost immunogenic cell death (ICD) to release “eat me” signals, and improve CD47‐blocking immunotherapy by tumor‐targeted codelivery of photosensitizer IR820 and anti‐CD47… read more here.
Keywords: eat signals; cd47; blocking immunotherapy; light activated ... See more keywords
Macrophages regulate the clearance of living cells by calreticulin
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DOI: 10.1038/s41467-018-06807-9
Abstract: Recently, Feng, Weissman and colleagues demonstrated that activated macrophages secrete calreticulin (CRT), which binds to the surface of viable target cells and marks them for removal by programmed cell phagocytosis (PrCP)1. CRT is one of… read more here.
Keywords: surface; viable cells; clearance; eat signals ... See more keywords
Exploiting Phagocytic Checkpoints in Nanomedicine: Applications in Imaging and Combination Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.642530
Abstract: Recent interest in cancer immunotherapy has largely been focused on the adaptive immune system, particularly adoptive T-cell therapy and immune checkpoint blockade (ICB). Despite improvements in overall survival and progression-free survival across multiple cancer types,… read more here.
Keywords: phagocytic checkpoints; nanomedicine applications; exploiting phagocytic; checkpoints nanomedicine ... See more keywords