The dimeric organization that enhances the microtubule end-binding affinity of EB1 is susceptible to phosphorylation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.241216
Abstract: Microtubules dynamics is regulated by the plus end-tracking proteins (+TIPs) in cells. End binding protein 1 (EB1) acts as a master regulator in +TIPs networks by targeting microtubule growing ends and recruiting other factors. However,… read more here.
Keywords: end binding; dimeric organization; eb1; binding affinity ... See more keywords
Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends
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DOI: 10.7554/elife.48117
Abstract: The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 has been attributed to high-affinity… read more here.
Keywords: eb1; microtubule; facilitates tip; growing microtubule ... See more keywords
Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant
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DOI: 10.7554/elife.84143
Abstract: A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities. We previously developed a light-sensitive variant of the microtubule plus… read more here.
Keywords: growth cone; eb1; light sensitive; sensitive variant ... See more keywords