SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01397-0
Abstract: Brown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found… read more here.
Keywords: brown fat; bat; sox4; ebf2 ... See more keywords
SUN-639 A Novel Truncating EBF2 Variant Impairs White Adipocyte Function in A Dominant Negative Manner
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.149
Abstract: Abstract Disclosure: D. Gilio: None. M.C. Foss de Freitas: None. E.A. Oral: Regeneron Pharmaceuticals, Amryt Pharmaceuticals, Ionis Pharmaceuticals Inc., Third Rock Ventures, Rejuvenate Bio, Novo Nordisk, Rhythm Pharmaceuticals, Fractyl Laboratories, Morphic Medical. T. Chun: None.… read more here.
Keywords: mice; function; adipocyte function; dominant negative ... See more keywords